domingo, 9 de agosto de 2015

Challenges in Studying Modifiable Risk Factors for Birth Defects. - PubMed - NCBI

Challenges in Studying Modifiable Risk Factors for Birth Defects. - PubMed - NCBI



 2015 Mar;2(1):23-30.

Challenges in Studying Modifiable Risk Factors for Birth Defects.

Abstract

Conducting research to identify modifiable risk factors for birth defects is difficult for a variety of reasons. While some challenges are familiar to researchers across many disciplines, the confluence of issues affecting birth defects research may not be well understood by those outside of the field. This article describes several methodological challenges to the study of birth defects and ways these challenges might be addressed: (1) ascertainment, definition and classification of birth defects; (2) exposure assessment on modifiable risk factors; (3) analytical challenges related to small numbers and multiple statistical tests; (4) the role of genetics, including the collection of specimens and analysis of genetic data; and (5) challenges in translating research and demonstrating public health impact. Understanding these issues is important for researchers planning studies, reviewers evaluating the scientific merit of results from these studies, and consumers of the research, including fellow researchers, policy makers, health care providers, and families.

KEYWORDS:

birth defects; case classification; case definition; public health impact; research methods

PMID:
 
26236577
 
[PubMed] 
PMCID:
 
PMC4516719
 [Available on 2016-03-01]

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