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Pathologic Changes in Wild Birds Infected with Highly Pathogenic Avian Influenza A(H5N8) Viruses, South Korea, 2014 - Volume 21, Number 5—May 2015 - Emerging Infectious Disease journal - CDC

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Pathologic Changes in Wild Birds Infected with Highly Pathogenic Avian Influenza A(H5N8) Viruses, South Korea, 2014 - Volume 21, Number 5—May 2015 - Emerging Infectious Disease journal - CDC





Volume 21, Number 5—May 2015

Research

Pathologic Changes in Wild Birds Infected with Highly Pathogenic Avian Influenza A(H5N8) Viruses, South Korea, 2014

Hye-Ryoung Kim, Yong-Kuk Kwon, Il Jang, Youn-Jeong Lee, Hyun-Mi Kang, Eun-Kyoung Lee, Byung-Min Song, Hee-Soo Lee, Yi-Seok Joo, Kyung-Hyun Lee, Hyun-Kyoung Lee, Kang-Hyun Baek, and You-Chan BaeComments to Author 
Author affiliations: Animal and Plant Quarantine Agency, Anyang, South Korea

Abstract

In January 2014, an outbreak of infection with highly pathogenic avian influenza (HPAI) A(H5N8) virus began on a duck farm in South Korea and spread to other poultry farms nearby. During this outbreak, many sick or dead wild birds were found around habitats frequented by migratory birds. To determine the causes of death, we examined 771 wild bird carcasses and identified HPAI A(H5N8) virus in 167. Gross and histologic lesions were observed in pancreas, lung, brain, and kidney of Baikal teals, bean geese, and whooper swans but not mallard ducks. Such lesions are consistent with lethal HPAI A(H5N8) virus infection. However, some HPAI-positive birds had died of gunshot wounds, peritonitis, or agrochemical poisoning rather than virus infection. These findings suggest that susceptibility to HPAI A(H5N8) virus varies among species of migratory birds and that asymptomatic migratory birds could be carriers of this virus.
Highly pathogenic avian influenza (HPAI) A virus infection of gallinaceous birds (e.g., poultry) is associated with high morbidity and mortality rates (1). Wild waterfowl, including ducks, are natural reservoir hosts for influenza A viruses and play a role in virus ecology and propagation. However, since 2003, repeated outbreaks of HPAI virus subtype H5N1 infection have occurred in poultry flocks in several Southeast Asia countries, resulting in high mortality rates among domestic ducks and wild migratory birds (2). Several studies have raised concern about the spread of HPAI virus by migratory birds (35).
Within the past 10 years, 4 outbreaks of HPAI A(H5N1) have occurred in South Korea (during winter and spring); migratory birds were identified as putative vectors (69). In 2014, an outbreak of HPAI A(H5N8) in South Korea led to the culling of millions of domestic poultry. Hundreds of sick and dead wild birds were collected and tested, and the results confirmed HPAI A(H5N8) virus infection (10,11). Examining the pathologic changes caused by H5N8 virus infection in different wild bird species is essential for understanding their role in the spread of this highly infectious virus. We therefore examined many of the dead or sick wild birds collected during an outbreak of HPAI A(H5N8) virus during 2014 and report the gross and histologic findings and the patterns of virus antigen expression. We examined 8 Baikal teals, 3 bean geese, 1 whooper swan, and 2 mallard ducks naturally infected with HPAI A(H5N8) virus.

Dr. Kim is a veterinary researcher at the Animal and Plant Quarantine Agency, Anyang, South Korea. Her research interests include the molecular epidemiology and pathology of avian viral disease.

Acknowledgments


We thank Hyuk-Man Kwon for excellent technical assistance.
This work was supported by a grant from the National Animal Disease Control Project and the Golden Seed Project (213005-04-1-SBA10) of the Ministry of Agriculture, Food and Rural Affairs of Korea.

References

  1. Swayne DESuarez DHighly pathogenic avian influenza. Rev Sci Tech2000;19:46382 .PubMed
  2. Chen HSmith GZhang SQin KWang JLi KAvian flu: H5N1 virus outbreak in migratory waterfowl. Nature2005;436:1912DOIPubMed
  3. Perkins LESwayne DEVaried pathogenicity of a Hong Kong–origin H5N1 avian influenza virus in four passerine species and budgerigars. Vet Pathol2003;40:1424DOIPubMed
  4. Teifke JPKlopfleisch RGlobig AStarick EHoffmann BWolf PPathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans. Vet Pathol2007;44:13743DOIPubMed
  5. Kwon YKThomas CSwayne DEVariability in pathobiology of South Korean H5N1 high-pathogenicity avian influenza virus infection for 5 species of migratory waterfowl. Vet Pathol2010;47:495506DOIPubMed
  6. Lee Y-JChoi Y-KKim Y-JSong M-SJeong O-MLee E-KHighly pathogenic avian influenza virus (H5N1) in domestic poultry and relationship with migratory birds, South Korea. Emerg Infect Dis2008;14:487DOIPubMed
  7. Kim H-RPark C-KLee Y-JWoo G-HLee K-KOem J-KAn outbreak of highly pathogenic H5N1 avian influenza in Korea, 2008. Vet Microbiol.2010;141:3626DOIPubMed
  8. Kim H-RLee Y-JPark C-KOem J-KLee O-SKang H-MHighly pathogenic avian influenza (H5N1) outbreaks in wild birds and poultry, South Korea. Emerg Infect Dis2012;18:4803DOIPubMed
  9. Lee C-WSuarez DLTumpey TMSung H-WKwon Y-KLee Y-JCharacterization of highly pathogenic H5N1 avian influenza A viruses isolated from South Korea. J Virol2005;79:3692702DOIPubMed
  10. Jeong JKang H-MLee E-KSong B-MKwon Y-KKim H-RHighly pathogenic avian influenza virus (H5N8) in domestic poultry and its relationship with migratory birds in South Korea during 2014. Vet Microbiol2014;173:24957DOIPubMed
  11. Lee Y-JKang H-MLee E-KSong B-MJeong JKwon Y-KNovel reassortant influenza A (H5N8) viruses, South Korea, 2014. Emerg Infect Dis.2014;20:10879DOIPubMed
  12. Ko KYShin JYKim D-GKim MSon S-WDetermination of organophosphorus pesticides in stomach contents of postmortem animals by QuEChERS and gas chromatography. J Anal Toxicol2014;38:66771 . DOIPubMed
  13. Perkins LESwayne DEPathobiology of A/chicken/Hong Kong/220/97 (H5N1) avian influenza virus in seven gallinaceous species. Vet Pathol.2001;38:14964DOIPubMed
  14. Keawcharoen JVan Riel Dvan Amerongen GBestebroer TBeyer WEVan Lavieren RWild ducks as long-distance vectors of highly pathogenic avian influenza virus (H5N1). Emerg Infect Dis2008;14:600DOIPubMed
  15. Kalthoff DBreithaupt ATeifke JPGlobig AHarder TMettenleiter TCPathogenicity of highly pathogenic avian influenza virus (H5N1) in adult mute swans. Emerg Infect Dis2008;14:1267DOIPubMed
  16. Brown JDStallknecht DEValeika SSwayne DESusceptibility of wood ducks to H5N1 highly pathogenic avian influenza virus. J Wildl Dis.2007;43:6607DOIPubMed
  17. Gaidet NCattoli GHammoumi SNewman SHHagemeijer WTakekawa JYEvidence of infection by H5N2 highly pathogenic avian influenza viruses in healthy wild waterfowl. PLoS Pathog2008;4:e1000127DOIPubMed
  18. Kim H-RKim B-SBae Y-CMoon O-KOem J-KKang H-MH5N1 subtype highly pathogenic avian influenza virus isolated from healthy mallard captured in South Korea. Vet Microbiol2011;151:3869DOIPubMed
  19. Swayne DEAlexander DJConfirmation of nephrotropism and nephropathogenicity of three low‐pathogenic chicken‐origin influenza viruses for chickens. Avian Pathol1994;23:34552DOIPubMed
  20. Bonfante FFusaro AZanardello CPatrono LVDe Nardi RManiero SLethal nephrotropism of an H10N1 avian influenza virus stands out as an atypical pathotype. Vet Microbiol2014;173:189200DOIPubMed
  21. Cardona CJXing ZSandrock CEDavis CEAvian influenza in birds and mammals. Comp Immunol Microbiol Infect Dis2009;32:25573.DOIPubMed
  22. Chan PKOutbreak of avian influenza A (H5N1) virus infection in Hong Kong in 1997. Clin Infect Dis2002;34(Suppl 2):S5864DOIPubMed
  23. Swayne DEPantin-Jackwood M. Pathobiology of avian influenza virus infections in birds and mammals. In: Swayne DE, editor. Avian influenza. Hoboken (NJ): John Wiley and Sons; 2008. p. 87–122.

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Suggested citation for this article: Kim HR, Kwon YK, Jang I, Lee YJ, Kang HM, Lee EK, et al. Pathologic changes in wild birds infected with highly pathogenic avian influenza A(H5N8) viruses, South Korea, 2014. Emerg Infect Dis. 2015 May [date cited]. http://dx.doi.org/10.3201/eid2105.141967
DOI: 10.3201/eid2105.141967

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