lunes, 20 de abril de 2015

Breast cancer subtype intertumor heterogeneity: MRI-based features predict results of a genomic assay. - PubMed - NCBI

Breast cancer subtype intertumor heterogeneity: MRI-based features predict results of a genomic assay. - PubMed - NCBI



 2015 Apr 7. doi: 10.1002/jmri.24890. [Epub ahead of print]

Breast cancer subtype intertumor heterogeneity: MRI-based features predict results of a genomic assay.

Abstract

PURPOSE:

To investigate the association between a validated, gene-expression-based, aggressiveness assay, Oncotype Dx RS, and morphological and texture-based image features extracted from magnetic resonance imaging (MRI).

MATERIALS AND METHODS:

This retrospective study received Internal Review Board approval and need for informed consent was waived. Between 2006-2012, we identified breast cancer patients with: 1) ER+, PR+, and HER2- invasive ductal carcinoma (IDC); 2) preoperative breast MRI; and 3) Oncotype Dx RS test results. Extracted features included morphological, histogram, and gray-scale correlation matrix (GLCM)-based texture features computed from tumors contoured on pre- and three postcontrast MR images. Linear regression analysis was performed to investigate the association between Oncotype Dx RS and different clinical, pathologic, and imaging features. P < 0.05 was considered statistically significant.

RESULTS:

Ninety-five patients with IDC were included with a median Oncotype Dx RS of 16 (range: 0-45). Using stepwise multiple linear regression modeling, two MR-derived image features, kurtosis in the first and third postcontrast images and histologic nuclear grade, were found to be significantly correlated with the Oncotype Dx RS with P = 0.0056, 0.0005, and 0.0105, respectively. The overall model resulted in statistically significant correlation with Oncotype Dx RS with an R-squared value of 0.23 (adjusted R-squared = 0.20; P = 0.0002) and a Spearman's rank correlation coefficient of 0.49 (P < 0.0001).

CONCLUSION:

A model for IDC using imaging and pathology information correlates with Oncotype Dx RS scores, suggesting that image-based features could also predict the likelihood of recurrence and magnitude of chemotherapy benefit. J. Magn. Reson. Imaging 2015.
© 2015 Wiley Periodicals, Inc.

KEYWORDS:

breast cancer subtypes; genotype; invasive ductal carcinoma

PMID:
 
25850931
 
[PubMed - as supplied by publisher]

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