lunes, 16 de marzo de 2015

Institutional protocol to manage consanguinity detected by genetic testing in pregnancy in a minor.

http://www.ncbi.nlm.nih.gov/pubmed/25687148?dopt=Abstract

 2015 Mar;135(3):e736-9. doi: 10.1542/peds.2014-2593.

Institutional protocol to manage consanguinity detected by genetic testing in pregnancy in a minor.

Abstract

Single-nucleotide polymorphism arrays and other types of genetic tests have the potential to detect first-degree consanguinity and uncover parental rape in cases of minor teenage pregnancy. We present 2 cases in which genetic testing identified parental rape of a minor teenager. In case 1, single-nucleotide polymorphism array in a patient with multiple developmental abnormalities demonstrated multiple long stretches of homozygosity, revealing parental rape of a teenage mother. In case 2, a vague maternal sexual assault history and diagnosis of Pompe disease by direct gene sequencing identified parental rape of a minor. Given the medical, legal, and ethical implications of such revelations, a protocol was developed at our institution to manage consanguinity identified via genetic testing.
Copyright © 2015 by the American Academy of Pediatrics.

KEYWORDS:

DNA sequence analysis; consanguinity; genetic testing; pregnancy in adolescence; rape; single nucleotide polymorphism
PMID:
 
25687148
 
[PubMed - in process] 
PMCID:
 
PMC4338324
 [Available on 2016-03-01]

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