Genomic Dissection of Travel-Associated Extended-Spectrum-Beta-Lactamase-Producing Salmonella enterica Serovar Typhi Isolates Originating from the Philippines: a One-Off Occurrence or a Threat to Effective Treatment of Typhoid Fever?

Hendriksen RS1, Leekitcharoenphon P2, Mikoleit M3, Jensen JD2, Kaas RS2, Roer L2, Joshi HB3, Pornruangmong S4, Pulsrikarn C4, Gonzalez-Aviles GD3,Reuland EA5, Al Naiemi N6, Wester AL7, Aarestrup FM2, Hasman H2.

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Abstract

One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. Typhi. The reported strain was similar to a previously published strain harboring blaSHV-12 from the Philippines and likely part of an undetected outbreak, the first of ESBL-producing S. Typhi.