lunes, 27 de octubre de 2014

Worldwide emergence of multiple clades of enterovirus 68

Worldwide emergence of multiple clades of enterovirus 68



J Gen Virol. Sep 2012; 93(Pt 9): 1952–1958.
PMCID: PMC3542132

Worldwide emergence of multiple clades of enterovirus 68

Introduction

Enteroviruses (family Picornaviridae, genus Enterovirus) are non-enveloped, positive-sense ssRNA viruses. Enteroviruses can cause a wide range of clinical symptoms, ranging from mild febrile illness to fatal meningitis and encephalitis and are among the most common human pathogens. A typical enterovirus genome consists of an RNA strand of approximately 7500 nt and contains a single ORF encoding a polyprotein that is processed post-translationally to yield individual viral proteins. The polyprotein ORF is flanked by a UTR at each end, with the 5′ UTR containing the highly conserved internal ribosome entry site (IRES) (). The VP1 gene, which encodes one of four capsid proteins, has traditionally been used to distinguish between enterovirus serotypes and, based on molecular and biological characteristics, four human enterovirus (HEV) species are currently recognized, designated HEV-A, -B, -C and -D ().

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