Tuberculosis: Genomics & Public Health

Genomics|Update|Current

Tuberculosis: Genomics & Public Health

Recent notes from the field: Use of genotyping to disprove a presumed outbreak of mycobacterium tuberculosis — Los Angeles County, 2013–2014 
MMWR  October 10, 2014  63(40);907-908

CDC article: Prioritizing tuberculosis clusters by genotype for public health action, Washington, USA, Emerging Infectious Diseases (2013)

CDC information: Using whole genome sequencing to improve tuberculosis outbreak detection and investigation effectiveness

CDC information on tuberculosis

Genomic insights into tuberculosis. 
James E. Galagan Nature Reviews Genetics, March 25, 2014

Culture-independent detection and characterisation of Mycobacterium tuberculosis and M. africanum in sputum samples using shotgun metagenomics on a benchtop sequencer
Emma L Doughty et al. Peer J, August 2014

IL-32 is a molecular marker of a host defense network in human tuberculosis
Dennis Montoya et al. Science Translational Medicine, August 20, 2014  

Did you know? More than 700 publications have reported on more than 330 genes in relation to tuberculosis susceptibility & outcomes, including 10 genomewide association studies. To find out more, visit the HuGE Navigator

Human genetics of tuberculosis: a long and winding road. 
Laurent Abeet al. Philos Trans R Soc Lond B Biol Sci. 2014 May 12;369(1645):20130428.