PLOS ONE: Molecular Epidemiology of Chronic Pseudomonas aeruginosa Airway Infections in Cystic Fibrosis
Molecular Epidemiology of Chronic Pseudomonas aeruginosa Airway Infections in Cystic Fibrosis
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1 Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hanover Medical School, Hanover, Germany, 2 Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, and Department of Clinical Microbiology, University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3 Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hanover, Germany
Abstract Top
Background/Methods
The molecular epidemiology of the chronic airway infections with Pseudomonas aeruginosa in individuals with cystic fibrosis (CF) was investigated by cross-sectional analysis of bacterial isolates from 51 CF centers and by longitudinal analysis of serial isolates which had been collected at the CF centers Hanover and Copenhagen since the onset of airway colonization over 30 years.Results
Genotyping revealed that the P. aeruginosa population in CF is dominated by a few ubiquitous clones. The five most common clones retrieved from the CF host also belonged to the twenty most frequent clones in the environment and in other human disease habitats. Turnover of clones in CF airways was rare. At the Hanover clinic more than half of the patient cohort was still harbouring the initially acquired clone after twenty years of airway colonization. At the Copenhagen clinic, however, two rare clones replaced the initially acquired individual clones in all but one patient.Conclusion
The divergent epidemiology at the two sites is explained by their differential management of hygiene and antipseudomonal chemotherapy. Hygienic measures to prohibit patient-to-patient transmission and the modalities of antipseudomonal chemotherapy modify the epidemiology of the chronic P. aeruginosa infections in CF.
Citation: Cramer N, Wiehlmann L, Ciofu O, Tamm S, Høiby N, et al. (2012) Molecular Epidemiology of Chronic Pseudomonas aeruginosa Airway Infections in Cystic Fibrosis. PLoS ONE 7(11): e50731. doi:10.1371/journal.pone.0050731
Editor: Erich Gulbins, University of Duisburg-Essen, Germany
Received: July 23, 2012; Accepted: October 24, 2012; Published: November 28, 2012
Copyright: © 2012 Cramer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: Financial support was received from the Deutsche Forschungsgemeinschaft (SFB 900, A2; GRK 653/3) and the Christiane Herzog Stiftung. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: tuemmler.burkhard@mh-hannover.de
Editor: Erich Gulbins, University of Duisburg-Essen, Germany
Received: July 23, 2012; Accepted: October 24, 2012; Published: November 28, 2012
Copyright: © 2012 Cramer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: Financial support was received from the Deutsche Forschungsgemeinschaft (SFB 900, A2; GRK 653/3) and the Christiane Herzog Stiftung. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
* E-mail: tuemmler.burkhard@mh-hannover.de
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